How many performers are you looking for?
I'm sure you've already considered All in the Timing and A Midsummer Night's Dream. (I know, All in the Timing is a collection of one-acts). There's your old warhorses (Arsenic and Old Lace, You Can't Take it With You, the Odd Couple (female version), Rumors, and Noises Off)
I hear this is very cool: chemical imabalance: a jekyll and hyde play - might be inappropriate for your audience, but it's been done in high schools:
http://www.dramatists.com/cgi-bin/db/single.asp?key=3902 - http://www.dramatists.com/cgi-bin/db/single.asp?key=3902
for a smaller cast, try Kimberly Akimbo
http://www.dramatists.com/cgi-bin/db/single.asp?key=3224 - http://www.dramatists.com/cgi-bin/db/single.asp?key=3224
From my own oevre, I'd suggest The Craving (just done at a Catholic school) - 10 females, 8 males, with some flexibility
Here's the blurb from playscripts:
"Screenwriter Terry Kyle Morris has just written his first screenplay, a heartwarming emotional journey. His dreams are answered when a big Hollywood studio decides to produce it, but the dream turns into a nightmare as they transform his beautiful script into a zombie slasher flick."
Read it online here for free:
http://www.playscripts.com/play.php3?playid=1425 - http://www.playscripts.com/play.php3?playid=1425
And I have a new play, Chemical Bonding, (14 females, 11 males, coming 2010 from Playscripts) -
here's the blurb:
"A heartfelt and hilarious comedic drama about a girl coming to grips with life the summer after graduating near the top of her class. Pressured into taking the worst summer job imaginable, third-shift at a chemical solvents factory, Dani must navigate life, love, illness, facebook, and insane relatives to somehow make her way to college."
Read the first 15 pages here:
http://www.donzolidis.com/full/chemicalbonding.pdf - http://www.donzolidis.com/full/chemicalbonding.pdf
I can send you the rest of the play if you're interested.
Z
------------- www.donzolidis.com
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